Potentially malignant disorders (PMD) of oral mucosa, with risk of conversion to oral squamous cell carcinoma (OSCC) are described in the literature as “pre-cancer”, “precursor lesions”, “premalignant”, “intraepithelial neoplasia” and “potentially malignant”. The term PMD was defined by the WHO as the risk of malignancy being present in a lesion or condition either during the initial diagnosis or in future date. Oral cancer incidence is highest in India and approx 90-95% oral cancer cases belong to OSCC group. The scale of PMD and oral cancer varies from place to place within the country. PMDs like leukoplakia, OSMF, erythroplakia, lichen planus and solar elastosis are commonly seen in India and carry increased risk of malignant transformation. Early identification of such PMDs is very important to prevent conversion to OSCC. Due to increase in Tobacco habits, dietary factors, environmental exposures and genetic factors, the incidence of PMDs is on the rise thus increasing the burden of OSCC. As patients from many primary health centres and district hospitals are referred to SCB Dental College and Hospital, a tertiary care centre, the study was planned to evaluate the prevalence of PMDs and malignant lesions. Routine patients attending the department of Oral Medicine & Radiology, SCB Dental College and Hospital, for a period of 5 years from 2012-2017 were included in the study. The study revealed leukoplakia constituted the highest number among the PMDs and OSCC was the most prevalent oral malignancy.