Abstract

Introduction: Uterine stromal neoplasm has always been a challenge to the pathologists for their non-specific clinical features, often indistinct gross features, overlapping histological features, and unpredicted immunohistochemical expression.This study was conducted to analyse the salient clinical morphologic & immunohistochemical characteristics of these tumors. Materials & methods: All histopathologically proven cases of endometrial stromal neoplasm at the department of Pathology over a period of 5 years were retrieved..the clinical morphological features were analysed. Results: We encountered 12 cases of endometrial stromal neoplasia. The spectrum included 3 cases of ESN, 5 cases of low grade ESS & 3 cases of high grade carcinosarcoma with a case of undifferentiated sarcoma . The mean age of presentation of carcinosarcomas (61 years) were a decade later as compared to ESS (46 years) & ESN (47 years). The ESN occurred in young adults . case of UUS at 26yrs. Menorrhagia with polypoid masses in the uterus . The age group of ESS-LG was perimenopausal with one case of intramural firm uterine mass. CD10 & SMA in 2 cases of LG-ESS showed positivity. The UUS showed positivity for vimentin, INI-1 & Ki 67 (50%). Conclusion: Evaluation of morphology with additional immunohistochemical analysis will lead to a conclusive diagnosis.