Lemur tyrosine kinase-3 (LMTK3) is a group of serine/threonine/tyrosine kinases that are found to be novel target for Estrogen receptor alpha positive breast cancer. In this study, LMTK3 domain is modelled and high throughput virtual screening studies were performed to identify potent LMTK3 inhibitors. Also, proteomic studies involving the interaction, stabilization and post translational modifications need to be investigated.