India is one of the high incidence zones in head & neck cancer. In india, the most common head & neck cancers are those of oral cavity and pharynx. Infact, mouth and pharynx cancers are third most common cancer in males and fourth most common in females in the developing countries. There are chances of good loco-regional control with anatomical and functional preservation in head and neck cancers. There is role of single modality ( surgery or rt ) in stage I / II disease. There is role of combined modality in stage III / IV disease – combined modality [surgery + RT (in most patients), chemotherapy + RT in selected patients] There is always role of multidisciplinary management including radiation oncologists, surgical oncologists, medical oncologists, radiologists, medical physicists, radiotherapy technologists, dentists / prosthodontics , speech and swallowing therapists, physical medicine & rehabilitation and social services in the management of head and neck cancers. There are a lot of early reactions like mucositis, dermatitis , increasing hoarseness, dysphagia, laryngeal edema. there are late reactions like late reactions xerostomia, laryngeal edema, subcutaneous fibrosis, pharyngeal stricture, osteoradionecrosis. The general management of stomatitis include gargles and hygiene analgesics and antiinflammatory, local anesthetics, local application gels, nasogastric feeding, gaps in treatment till stomatitis decreases,parenteral feeding. There is evidence suggesting effectiveness of commonly used mouthwashes for the prevention of chemotherapy and radiotherapy induced oral mucositis. Thus it is important to use validated tools to regularly assess oral pain & hygiene.There is important role of dental professionals: vital before initiation of therapy as well as throughout treatment & follow up.The technique of Radiotherapy also determines the course of early and late reactions and thus conformal therapies have come up in a big way.There is now documented role Benzydamine gargles: anti-inflammatory with analgesic, anesthetic & anti-microbial properties reduces frequency & severity of ulcerative lesions.Lot of research papers prove role of other agents like Amifostine, Pilocarpine etc.Palliation of acute oral pain: most important component of patient care.